Brain cancer mortality rates increase with Toxoplasma gondii seroprevalence in France.
نویسندگان
چکیده
The incidence of adult brain cancer was previously shown to be higher in countries where the parasite Toxoplasma gondii is common, suggesting that this brain protozoan could potentially increase the risk of tumor formation. Using countries as replicates has, however, several potential confounding factors, particularly because detection rates vary with country wealth. Using an independent dataset entirely within France, we further establish the significance of the association between T. gondii and brain cancer and find additional demographic resolution. In adult age classes 55 years and older, regional mortality rates due to brain cancer correlated positively with the local seroprevalence of T. gondii. This effect was particularly strong for men. While this novel evidence of a significant statistical association between T. gondii infection and brain cancer does not demonstrate causation, these results suggest that investigations at the scale of the individual are merited.
منابع مشابه
Incidence of adult brain cancers is higher in countries where the protozoan parasite Toxoplasma gondii is common.
We explored associations between the common protozoan parasite Toxoplasma gondii and brain cancers in human populations. We predicted that T. gondii could increase the risk of brain cancer because it is a long-lived parasite that encysts in the brain, where it provokes inflammation and inhibits apoptosis. We used a medical geography approach based on the national incidence of brain cancers and ...
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عنوان ژورنال:
- Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
دوره 12 2 شماره
صفحات -
تاریخ انتشار 2012